We’re delighted to announce the start of an international research project under the European Consortium for Continuous Pharmaceutical Manufacturing (ECCPM). The collaborative efforts from industrial and scientific partners aim to develop continuous manufacturing practices and improve the quality and cost-effectiveness of nanoparticles-based drug products. Utilizing cutting-edge technology and innovative techniques, we’re paving the way for a new era of production and nanomedicine.

Small scale to large scale: a major issue for the industrial transfer The manufacturing of pharmaceutical tablets is a complex process involving several steps, like powder granulation or compression in which various problems can occur. The ultimate goal of the development teams is to result in a manufacturing process that guarantees the product quality. One … Continue reading Process scale-up: how to ensure the right first time ?

This week, SpeakPharma interviews David Lescuyer, CEO, and Benoit Mougeot, CFO, of Skyepharma, a fully integrated Frenche CDMO for complex oral solid dosage forms. Over the last six years, Skyepharma has transformed itself from a basic contact manufacturing organization (CMO) to an agile, expert, and differeniated contract development and manufacturing organization (CDMO). See more in … Continue reading Skyepharma: the specialized CDMO growing in double digits

Press-coated tablets are an advantageous technology to achieve delayed releases of active ingredients. They are characterized by a core–shell structure, that makes it possible to tune the lag-time and release kinetics in order to meet the chronotherapeutical goals. Thus, these features are the most important quality attributes to be controlled when designing a press-coated tablet. … Continue reading Controlling the lag-time and release kinetics of
press-coated tablets using process parameters
and tablet geometry

Skyepharma funds a PhD thesis in collaboration with Bordeaux University, with the aim to expand deep physical and mechanical comprehension of complex tablet behaviors, with a specific focus on press coated tablets.   INTRODUCTION With growing interest in chronotherapeutics, the technologies of modified drug release become of major importance, as well as the good control … Continue reading Opening modes and release rate of the press-coated tablets (Tab-in-Tab): influence of compression parameters and tablet geometry

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Skyepharma reinforces its strong collaboration with Lyon University to develop an eco-friendly process to take up the challenge of improving bioavailability of poorly soluble APIs. Very promising results are obtained with different Solid Lipid Nanoparticles and Nanostructured Lipid Carriers. INTRODUCTION Oral drug administration is the preferred route because it ensures better patient compliance to their … Continue reading Microfluidization : an eco-friendly process to improve oral bioavailability of poorly soluble API

Pour se démarquer des autres sous-traitants pharmaceutiques, Skyepharma fait le choix de l’innovation. Un choix audacieux que nous expliquent David Lescuyer, président et directeur général, et Laurent Rigaudeau, directeur commercial.

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RESEARCH ON PRESS-COATED TABLETS GOES ON The partner research teams of Skyepharma and University of Bordeaux have recently published a second peer-reviewed article on topics of press-coated tablets. This paper, released in International Journal of Pharmaceutics, focuses on the diametral compression test, that is much more complex for the press-coated tablets than for single-layer tablets. … Continue reading Diametral test of press-coated tablets – Complexity and challenges

Join us for a discussion of the Eco-friendly process to improve oral bioavailability of poorly soluble API       Session Abstract Many factors limit the effectiveness of oral treatments, including the poor bioavailability of some Active Pharmaceutical Ingredients (API). Considering these issues, particle size reduction and nanoencapsulation of BCS class II or IV API … Continue reading Innovative solvent-free technology for oral bioavailability enhancement

Skyepharma recently decided to partner with Veratrak to answer customers and market’s needs in terms of exchange of data. Indeed, the amount and the size of documents exchanged between CDMO and their partners is sharply and constantly increasing. As data integrity and confidentiality are now additional constraints to take into account, it became critical for … Continue reading Why using the Veratrak plateform ?

Pharmaceutical Context & Patient Oriented Needs Skyepharma is providing a number of services to answer the various clients and the different medical needs that are unmet today. Specifically, it is of common knowledge that the pharmaceutical market is continuously evolving and currently moving to the 3rd and/or 4th generations of drugs which are now targeting … Continue reading Skyepharma : Expert CDMO in the Compression of Complex Tablets

It is an exciting time for our company, with the June 9th, 2021, announcement of a management buyout (MBO) and the establishment of Skyepharma as an independent company. What is the rationale behind this deal ? {{ vc_btn: title=Read+full+article+here&style=gradient&gradient_color_2=vista-blue&align=center&css_animation=appear&link=url%3Ahttps%253A%252F%252Fpharmaboardroom.com%252Fsponsored%252Fnewly-independent-cdmo-skyepharma-looks-to-expansion }} You liked this reading? Feel free to contact us ! Your name Your email Your … Continue reading Newly Independent CDMO Skyepharma Looks to Expansion

What is the PMI? The PMI, Project Management Institute, is a non-profit professional association, which mainly addresses project managers. It is this organization that governs the "bible" of the project manager: PMBOK or Project Management Body of Knowledge, but also delivers the PMP or Project Management Professional certification. Internationally recognized, this qualification allows Skyepharma to … Continue reading PMI : Project Management Institute

In pharmaceutical industries, UHPLC is becoming more and more essential due to its accessibility and its chromatographic performance. Skyepharma’s AD/QC laboratory has strengthened its analytical range by the acquisition of H-Class acquity UPLCs, state of art equipment in liquid chromatography field for routine analysis and analytical development. Chromatographic analysis, the laboratory core analysis The UHPLC … Continue reading UHPLC : The analytical answer to current needs

Film coating of solid oral drugs is a well-established process in the pharmaceutical industry.   A tailor-made coating for your tablets Skyepharma is extending its fleet of coating equipment with a brand-new LC M50 machine (O’HARA technologies). Skyepharma is now able to propose coating services from early development to industrial commercial batches with development strategies … Continue reading Coating your oral solid drugs protect & optimize! Mastering the coating process

Recently, the partner research teams of Skyepharma and University of Bordeaux published an article in the International Journal of Pharmaceutics, which makes it the first peer-reviewed paper of Skyepharma. This work on press-coated tablets and their compression process has revealed new design parameters that are critical in development and manufacture of this type of tablets. … Continue reading Press-coated tablets: Increase knowledge through research

Learn how Microfluidizer® Technology could boost the effectiveness of your drug! The low bioavailability of active pharmaceutical ingredients (API) is one of the major hurdles in the development of oral drug formulations. Indeed, poor solubility and/or permeability of therapeutic molecules results in low preclinical efficacy that can sometimes lead to the premature abandonment of some … Continue reading Bioavailability is a matter of size!

Après une année de bouleversements économiques, sociaux et organisationnels, les managers ont rarement joué un rôle aussi important que pendant cette pandémie mondiale. Heureusement, chez Skyepharma, cela fait 4 ans que l’équipe travaille sur la culture managériale de l’entreprise, que la nouvelle équipe de management porte cette culture, et que les managers sont formés puis … Continue reading Culture managériale : Être un manager à la fois bienveillant et efficient

Since 2016, Skyepharma has been transforming itself. « Our goal: to be a renowned Center of Excellence from formulation and pharmaceutical development, to full manufacturing and packaging of complex solid forms » says David Lescuyer, President of Skyepharma Production S.A.S. An ambitious strategic plan has been implemented with different work leads Firstly, developing the staff with experienced … Continue reading Skyepharma – Center of Excellence in Formulation & Pharmaceutical Development and Manufacturing

Are you looking for a subcontractor to deliver the precise and unique dose to your patients? We have the solution. New packaging line at Skyepharma   Early 2021, Skyepharma will complement its offer in oral solid dosage forms with the acquisition of a stick-pack filling line.They can be filled with powder, pellets or granules. This … Continue reading Coming soon: Stick pack, a convenient unique dose for your patients

Extended value proposition by Skyepharma   In a process of continuous improvement, we are challenging ourselves every day to achieve optimal product quality for our customers. Particle size reduction by grinding, after granulation process, is often necessary to meet the strict specifications required by our clients.   Why has Skyepharma invested in high quality Frewitt … Continue reading New sieving equipment for powder size reduction in oral solid dosage form manufacturing

by Pharmaceutical Networking Since 2017, Skyepharma takes up great challenges ! Today, we have an annual production which is growin with 2 billion tablets, 300 million capsules, 30 million blisters, 6 million bottles and 20 million stick-packs ! In this respect Skyepharma has increased its logistics and manufacturing capabilities while meeting regulatory requirements. Operating on … Continue reading Skyepharma Identity in Facts and Figures

Examples of challenges successfully met with modified release tablets   On December 2, 2020, Dr. Mathieu Degomme, Pharmaceutical Project Manager at Skyepharma, hosted a webinar to present our modified release tablets technologies by illustrating them with concrete examples. Skyepharma has a strong experience in the development of complex tablet formulations since 1996 based on our … Continue reading Webinar – Modified release tablets: from Early Stage Development to Life Cycle Management

From early stage formulation design up to commercial production, how to guarantee tablet quality when it is complex formulations ? How to fasten and de-risk the development and the scale up stages ? Switch to Quality by Design !   How many of you have never experienced issues in completing your drug product development project: … Continue reading Quality by Design – How Skyepharma helps its clients to implement this highly valuable scientific approach

Limited business travel   During the containment period it was impossible for Skyepharma to receive visit from prospects and clients. However, the site visit stage is crucial in the negotiation and start-up of a new project with a CDMO. This constraint jeopardized the smooth running of projects and could therefore impact the timely delivery of … Continue reading Skyepharma’s 360° virtual tour

Skyepharma is specialized in developing and manufacturing complex and classic oral solid dosage forms. Our activities therefore cover a wide range of therapeutic indications. All the way through drug development and manufacturing process, our teams work with the objective of providing the most appropriate treatment to address patients' needs. As of today, we are working … Continue reading Therapeutic indications of products manufactured at Skyepharma

by ondrugdelivery Leading pharmaceutical development in a sustainable way   This article describes how the company fulfils its sustainable development policy through its technologies and processes. We have set up a sustainability development committee that handles projects such as energy cost reduction, waste recycling, preserving site fauna and flora, environmental awareness and ISO 14001 certification … Continue reading Sustainable development policy at Skyepharma

by pharmaceutical-networking. Do you have a project that requires Russian serialisation? Skyepharma is now able to offer similar locally adapted fully serialised and aggregated supplies to Russia. We can offer you as a global service or stand-alone service. Many manufacturers do not have the capacity to comply with Russian legislation which is very complex. Our … Continue reading Skyepharma overcomes Russian serialisation complexities

by pharmaceutical-networking. Skyepharma's team is now ready to use the virtual platform of the Festival of Pharma ! We are totally convinced of this new digital meeting tool to discuss and meet together. Do not hesitate to schedule a meeting with us by clicking on the link. This digital event will use an ergonomic plateform to … Continue reading Skyepharma is ready for virtual CPhI Festival of Pharma 2020

How Skyepharma helps its clients for EU, US, Russian and all other markets ? Why serialization in the pharmaceutical industry?   More and more medicines are being counterfeited or falsified. Currently 10% of medicines sold worldwide are counterfeit which causes serious damage to public health. This presents a risk to the patient and brings problems … Continue reading Serialization and aggregation in the pharmaceutical industry

By PharmaBoardroom. During this COVID-19 pandemic, pharmaceutical companies and authorities have more than ever understood the importance of a robust supply chain. At Skyepharma we have understood and anticipated this because we have been working on improving our supply chain during the past 4 years. Our agility allowed us to minimize the impact of the … Continue reading Supply Chain Reliability at Skyepharma, David Lescuyer’s Interview

As a full CDMO, Skyepharma has an analytical service that covers all aspects from development to production. This makes it possible to control packaging, raw materials and finished products. This service is proof that we want to provide a complete subcontracting offer. {{ vc_btn: title=Read+the+full+article+here&style=gradient-custom&gradient_custom_color_1=%230a9876&gradient_custom_color_2=%23283583&size=lg&align=center&link=url%3Ahttps%253A%252F%252Fwww.pharmaceutical-networking.com%252Fskyepharma-analytical-services%252F%7C%7Ctarget%3A%2520_blank%7C }} You liked this reading? Feel free to contact us … Continue reading Skyepharma Analytical Services : Specialized teams

Empower 3 and data integrity   As a CDMO we have to anticipate and go beyond on quality and regulatory topics. We are engaged in using reliable tools (such as Empower 3) in daily use. It's an unavoidable part of our company culture. Empower 3 allows acquisition, processing and editing of chromatographic analysis results. Data … Continue reading Empower 3 implementation – A step towards data integrity and operational excellence

Data integrity management at Skyepharma   Customers are of course attentive to CDMO's compliance with regulations. But they are even more attentive to the ability of CDMO to go beyond the authorities’ expectations. Data integrity is a good example. What do we mean by data integrity? The purpose of controlling data integrity in the pharmaceutical … Continue reading Skyepharma CDMO working on data integrity policy to foster its growth

BIO Digital   BIO International Convention has adapted to our current situation and offers a virtual version of its event initially planned in San Diego, USA. It's BIO digital. "We may not be able to meet in person, but there is no stopping innovation". And this global virtual gathering will allow us to meet and … Continue reading Skyepharma attending BIO Digital – A great opportunity for R&D projects

So-called orphan drugs are developed to treat rare diseases that are life-threatening or chronically debilitating.  In the US, a disease is orphan if fewer than 200,000 people are affected while in Europe the prevalence should be not more than 5 in 10,000. Although the assignment of the orphan status confers an extended period of market … Continue reading Formulation development : Ongoing orphan drugs development projects

In October 2019, we announced the beginning of an academic collaboration on Tab-in-Tab with the Laboratoire de Pharmacie Galénique et de Biopharmacie de Bordeaux, a member of the Institut de Mécanique et d'Ingénierie. Topic and challenges of the thesis   This collaboration is part of a doctoral thesis, under the supervision of Professor Pierre Tchoreloff … Continue reading R&D: Collaborative thesis on the mechanical resistance of tab-in-tab tablets – Progress to date.

Building on strong track record of FDA approvals since 1998   Today, Skyepharma Production SAS announces that it has successfully passed an FDA (Food and Drug Authority) inspection which took place earlier in September 2019. The company did not receive an FDA Form 483, which underpins the quality of its manufacturing and scientific facilities and … Continue reading Reconfirmation of FDA compliance

Reliable partnership   Skyepharma Production SAS, (“Skyepharma”) the contract development and manufacturing organization (CDMO) specialists in the development, manufacturing and packaging of classic and complex oral solid dosage forms, and Therabel, a privately-owned pharmaceutical group today announce their strengthened partnership for the production of Therabel’s solid form manufacturing. The agreement, which commenced in September 2018, … Continue reading Therabel group strengthens partnership with Skyepharma Production

Meet us at BIO International Convention   At BIO International Convention, Skyepharma will attend to communicate tailored capabilities for pharmaceutical development and manufacturing. As a CDMO, Skyepharma can help clients from the early development stage to the commercial manufacturing and packaging, offering agility and flexibility that are key added values for pharmaceuticals, delivering accelerated times … Continue reading Skyepharma is attending BIO International Convention

Skyepharma, focused on Right First Time for the benefit of the customer   At Skyepharma, we ensure Right First Time (RFT) for customers by leveraging the experience and skills of our production and quality technicians. This initiative is part of a global lean management project started in 2016 on the Skyepharma site. We make the … Continue reading Managing Right First Time from the ground up at Skyepharma

At Skyepharma we are proud to announce the creation of a new Customer Service department.   This decision was made, driven by the desire to ensure the best customer experience for our partners and potential customers. Nowadays customers expect their CDMOs to understand their needs, anticipate and offer tailored solutions to ensure on-time and trouble-free … Continue reading Skyepharma focused on customer experience

Meet us in Vienna   At Bio Europe Spring 2019, Skyepharma will attend to meet new partners to develop, manufacture, pack and market new pharmaceutical products for the global market. We are proud to present the end to end capabilities we have, including fully integrated development, packaging and commercial manufacturing, all lead by fully committed … Continue reading Skyepharma is attending BIO-Europe Spring

Successful transformation into a fully integarted CDMO   Over the last two years a significant and highly successful transformation has taken place at the Skyepharma site in Lyon, France. The mission has been to transform the site into a fully integrated CDMO (Contract Development and Manufacturing Organisation) with services extending from early stage development and … Continue reading Skyepharma is continuing its successful transformation to a fully integrated, expert and agile CDMO !

For the 2019 edition of Pharmapack, the magazine "Emballages Magazine" has decided to publish a journal dedicated to the traceability (serialization and aggregation) of pharmaceutical products. Indeed, since February 9, 2019, the standard for serialization of drug cartons has become mandatory for the European market. Aggregation will be mandatory as of November 1, 2023. In … Continue reading Skyepharma Already Set-up for Serialization and Aggregation

Skyepharma CDMO is Ready for serialization and aggregation.   The pharmaceutical serialization requirements are already effective in the United States and will become mandatory for the European market on 9th February 2019. With its two brand new packaging lines, Skyepharma is fully prepared to package, serialize and aggregate your tablets or capsules in bottles or … Continue reading Skyepharma ready for serialization and aggregation – Visit to Pharmapack

Organizational culture is a key to delivering excellence !   “Organizational culture eats strategy for breakfast, lunch and dinner” is a phrase originated by Peter Drucker and made famous by Mark Fields, President at Ford.   “It reminds us that companies with the ability to develop a strong and empowering culture with their employees can … Continue reading Skyepharma organizational culture

Our experience in lean management   GEMBA walks are an important part of lean management at Skyepharma. Lean management is a significant element in creating value and optimizing work processes. “GEMBA. What a wonderful word. The place - any place in any organisation – where humans create value.” This is the opening paragraph of the … Continue reading Lean Management – GEMBA walks

We recently acquired new laboratory equipment for automated bacteria and yeasts identification and for pore size analyser. Laboratory equipemnt 1 : BET Analyzer Skyepharma’s Analytical Development department recently acquired a BET Analyzer, used for Surface area and Pore Size Analysis. With this new tool, Skyepharma’s dedicated Analytical team is able to study the porous structure of raw … Continue reading Skyepharma invests in state-of-the-art laboratory equipment

Our tools to improve time to market   David LESCUYER – EVP Oral Business, Vectura Group of Companies – President of SKYEPHARMA PRODUCTION SAS: “With over 20 years of experience in complex oral solid dosage forms, we help our customers on reformulation, Life Cycle Management, trouble shooting, scale up and technical transfer of their products. … Continue reading Skyepharma improves time to market

New Marchesini bottling line   4.1 million Investment results in upgrade to SKYEPHARMA Development & Manufacturing site in Lyon. Acquisition of a new Marchesini bottling line will improve capacity and capabilies from March 2018. David LESCUYER – EVP Vectura Group of Companies – President of SKYEPHARMA PRODUCTION SAS: “With all the investments made on our … Continue reading Skyepharma acquires a new marchesini bottling line

The ultimate solid dosage tool to accelerate time to market, Skyepharma, a user experience feedback :   Skyepharma has recently invested in the tableting instrument STYL’ONE Evolution, the latest generation of compaction simulator from Medelpharm, for the development and scale up of its products. We shared our experience using this solid dosage tool in an … Continue reading Skyepharma’s investment in a tableting instrument